HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (pressure H and Con1) are infectious for the human hepatoma cell traces Huh-7 and PLC/PR5. Infectivity will depend on coexpression of each E1 and E2 glycoproteins, is pH-dependent, and could be neutralized by mAbs mapping to amino acids 412-447 inside E2. Cell-surface expression of 1 or all the candidate receptor molecules (CD81, low-density lipoprotein receptor, scavenger receptor class B sort 1, and dendritic cell-specific intercellular adhesion molecule three grabbing nonintegrin) didn’t confer permissivity to HIV-HCV pseudotype an infection. Nonetheless, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble type of CD81 and a mAb particular for CD81, suggesting that CD81 could…
C terminus, Chlamydomonas, Exosomes, glycoproteins, Hepatitis C virus, HIV, lipoprotein, mediate, Medium & Serums, morphogenesis, NATtrol, nonmotile, Panel, PCR, pH-dependent cell, PLC, polypeptides, pseudotyped retroviral particles, recombinant, Recombinant Proteins, retroviral, Ria Kits