Particle production from full-length human immunodeficiency

The human immunodeficiency virus sort 1 (HIV-1) Gag protein precursor, Pr55Gag, comprises at its C-terminal finish a proline-rich, 6-kDa area designated p6. Two capabilities have been proposed for p6: incorporation of the HIV-1 accent protein Vpr into virus particles and virus particle manufacturing.

 

To characterize the position of p6 within the HIV-1 life cycle and to map purposeful domains inside p6, we launched numerous nonsense and single and a number of amino acid substitution mutations into p6. Following the introduction of the mutations into the full-length HIV-1 molecular clone pNL4-3, the consequences on Gag protein expression and processing, virus particle manufacturing, and virus infectivity have been analyzed.

 

The manufacturing of mutant virus particles was additionally examined by transmission electron microscopy. The outcomes point out that (i) p6 is required for environment friendly virus particle manufacturing from a full-length HIV-1 molecular clone; (ii) a Professional-Thr-Ala-Professional sequence, situated between residues 7 and 10 of p6, is vital for virus particle manufacturing; (iii) mutations outdoors the Professional-Thr-Ala-Professional motif have little or no impact on virus meeting and launch; (iv) the p6 defect is manifested at a late stage within the budding course of; and (v) mutations in p6 that severely cut back virion manufacturing in HeLa cells additionally block or considerably delay the institution of a productive an infection within the CEM (12D-7) T-cell line.

Mouse Semaphorin- 6C, Sema6c ELISA KIT
ELI-07291m 96 Tests
EUR 865.00
Human Semaphorin- 6C ELISA Kit
ELA-E2277h 96 Tests
EUR 824.00
Human Semaphorin 6C (SEMA6C) ELISA Kit
abx519952-96tests 96 tests
EUR 668.00
Rat Semaphorin 6C (SEMA6C) ELISA Kit
abx519954-96tests 96 tests
EUR 668.00
Human Semaphorin- 6C, SEMA6C ELISA KIT
ELI-07292h 96 Tests
EUR 824.00
Human Semaphorin 6C(SEMA6C)ELISA Kit
GA-E0766HM-48T 48T
EUR 289.00
Human Semaphorin 6C(SEMA6C)ELISA Kit
GA-E0766HM-96T 96T
EUR 466.00
Human Semaphorin 6C (SEMA6C)ELISA Kit
201-12-0750 96 tests
EUR 440.00
Description: A quantitative ELISA kit for measuring Human in samples from biological fluids.
Human Semaphorin 6C(SEMA6C)ELISA Kit
QY-E00786 96T
EUR 361.00
Anti-Mouse Ly-6c antibody
STJ16100768 100 µg
EUR 604.00
Anti-Rab 6C antibody
STJ95303 200 µl
EUR 197.00
Description: Rabbit polyclonal to Rab 6C.
Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN 50 µg
EUR 349.00
Sarafotoxin 6c
5-01901 4 x 1mg Ask for price
anti-Anti-Semaphorin 5A
YF-PA25252 50 ul
EUR 334.00
Description: Mouse polyclonal to Anti-Semaphorin 5A
anti-Semaphorin 3B
YF-PA15485 100 ug
EUR 403.00
Description: Rabbit polyclonal to Semaphorin 3B
anti-Semaphorin 3D
YF-PA22776 50 ug
EUR 363.00
Description: Mouse polyclonal to Semaphorin 3D
anti-Semaphorin 3D
YF-PA22777 100 ug
EUR 403.00
Description: Rabbit polyclonal to Semaphorin 3D
anti-Semaphorin 3B
YF-PA25020 50 ul
EUR 334.00
Description: Mouse polyclonal to Semaphorin 3B
anti-Semaphorin 7a
YF-PA25109 50 ul
EUR 334.00
Description: Mouse polyclonal to Semaphorin 7a
anti-Semaphorin 3A
YF-PA25559 50 ul
EUR 334.00
Description: Mouse polyclonal to Semaphorin 3A
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1A(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1A(V25) 25 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1B(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1B(V25) 25 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1CFB(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1CFB(V25) 25 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1F(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1F(V25) 25 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1F(V500) 500 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PE(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PE(V25) 25 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PP(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PP(V25) 25 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PP55(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PP55(V25) 25 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PU(V100) 100 ug
EUR 50.00
Mouse Anti-Ly-6G/Ly-6C (Gr-1)
MOGR-1PU(V500) 500 ug
EUR 50.00
Anti Mouse Semaphorin 3B Polyclonal Antibody
KR100
EUR 649.00
Description: The Anti Mouse Semaphorin 3B Polyclonal Antibody is available in Europe and for worldwide shipping via Gentaur.
Anti-Semaphorin 5A antibody
STJ70970 100 µg
EUR 359.00
Anti-Semaphorin 7a (3D3)
YF-MA16372 100 ug
EUR 363.00
Description: Mouse monoclonal to Semaphorin 7a
Anti-Semaphorin 7a (1G1)
YF-MA16373 100 ug
EUR 363.00
Description: Mouse monoclonal to Semaphorin 7a
Anti-Semaphorin 3A (5G9)
YF-MA17274 50 ug
EUR 363.00
Description: Mouse monoclonal to Semaphorin 3A
Anti-Semaphorin 4D (3B4)
YF-MA17342 100 ug
EUR 363.00
Description: Mouse monoclonal to Semaphorin 4D
Polyclonal Goat anti-GST α-form
GST-ANTI-1 50 uL
EUR 280.00
Polyclonal Goat anti-GST μ-form
GST-ANTI-2 50 uL
EUR 280.00
Polyclonal Goat anti-GST p-form
GST-ANTI-3 50 uL
EUR 280.00
Anti-Semaphorin 3A/SEMA3A Antibody
A01761-1 100ug/vial
EUR 294.00
Anti-Semaphorin 3c/SEMA3C Antibody
A06444-1 100ug/vial
EUR 294.00
Anti-Semaphorin 3B/SEMA3B Antibody
A06559-1 100ug/vial
EUR 294.00
Anti-SEMA4A/Semaphorin 4A Antibody
A06779-1 100ul
EUR 397.00
Description: Rabbit Polyclonal Antibody for SEMA4A Antibody (SEMA4A) detection.tested for WB in Human, Mouse, Rat, Monkey.
Anti-Semaphorin 3E/SEMA3E Antibody
A06937-2 100ug/vial
EUR 294.00
Anti-SEMA4C/Semaphorin 4C Antibody
A08069 100ul
EUR 397.00
Description: Rabbit Polyclonal SEMA4C/Semaphorin 4C Antibody. Validated in WB and tested in Human.
Anti-Semaphorin 3A/SEMA3A Antibody
PB9353 100ug/vial
EUR 294.00
Anti-Semaphorin 3E (internal) antibody
STJ71055 100 µg
EUR 359.00
Bio-6C-SAH 1b
ACT00303-100 100µg
EUR 806.00
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid.
Bio-6C-SAH 1a
ACT00303-50 50µg
EUR 475.00
Description: Biotin is conjugated to NH2 of SAH through 6-aminohexanoic acid.
Dig-6C-SAH 1c
ACT00304-100 100µg
EUR 943.00
Description: Digoxin is conjugated to NH2 of SAH through 6-bromocaproic acid.
Dig-6C-SAH 1a
ACT00304-25 25µg
EUR 358.00
Description: Digoxin is conjugated to NH2- of SAH through 6-bromocaproic acid
Dig-6C-SAH 1b
ACT00304-50 50µg
EUR 621.00
Description: Digoxin is conjugated to NH2 of SAH through 6-bromocaproic acid.
Rab 6C Polyclonal Antibody
ES3292-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against Rab 6C from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA
Rab 6C Polyclonal Antibody
ES3292-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against Rab 6C from Human/Mouse/Rat. This antibody is tested and validated for WB, ELISA, WB, ELISA
6C-aza-SAM (Biotin)
20-abx083016
  • EUR 1233.00
  • EUR 342.00
  • EUR 746.00
  • 0
  • 1
  • 2
Keratin 6C (KRT6C) Antibody
20-abx128996
  • EUR 425.00
  • EUR 133.00
  • EUR 1205.00
  • EUR 578.00
  • EUR 328.00
  • 0
  • 1
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Rab 6C Polyclonal Antibody
ABP52293-003ml 0.03ml
EUR 158.00
Description: A polyclonal antibody for detection of Rab 6C from Human, Mouse, Rat. This Rab 6C antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6C at AA range: 140-220
Rab 6C Polyclonal Antibody
ABP52293-01ml 0.1ml
EUR 289.00
Description: A polyclonal antibody for detection of Rab 6C from Human, Mouse, Rat. This Rab 6C antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6C at AA range: 140-220
Rab 6C Polyclonal Antibody
ABP52293-02ml 0.2ml
EUR 414.00
Description: A polyclonal antibody for detection of Rab 6C from Human, Mouse, Rat. This Rab 6C antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the Internal region of human Rab 6C at AA range: 140-220
Keratin 6C (KRT6C) Antibody
abx027868-400ul 400 ul
EUR 523.00
Keratin 6C (KRT6C) Antibody
abx027868-80l 80 µl
EUR 286.00

We additional display that mutational inactivation of the viral protease reverses the p6 defect, suggesting a purposeful linkage between p6 and the proteolytic processing of the Gag precursor protein through the budding of progeny virions.

 

A subcomplex of the proteasome regulatory particle required for ubiquitin-conjugate degradation and associated to the COP9-signalosome and eIF3.

 

  • Human cytomegalovirus (HCMV), a member of the herpesvirus household, is a big advanced enveloped virus composed of each viral and mobile gene merchandise.

Anti-SLAM/CD150 antibody

PAab07902 100 ug
EUR 412.00

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349.00

anti-SLAM anti-CDw150 IgG2a mAb

059-A-01mg 0,1 mg
EUR 267.50
Description: anti-SLAM anti-CDw150 IgG2a (monoclonal) Produced against an activated B cell line.

anti-SLAM anti-CDw150 IgG2a mAb

059-A-1000ug 1000 ug
EUR 1282.50
Description: anti-SLAM anti-CDw150 IgG2a (monoclonal) Produced against an activated B cell line.

SLAM antibody

10R-CD150a 100 ug
EUR 349.00
Description: Mouse monoclonal SLAM antibody

Anti-SH2D1A/SLAM associated protein antibody

STJ70814 100 µg
EUR 359.00

SLAM/CD150 Antibody

3226-200
EUR 338.00

SLAM/CD150 Antibody

3226-30T
EUR 146.00

SLAM Polyclonal Antibody

41685-100ul 100ul
EUR 252.00

SLAM Polyclonal Antibody

41685-50ul 50ul
EUR 187.00

SLAM / CD150 Antibody

abx237902-100ug 100 ug
EUR 551.00

SLAM Polyclonal Antibody

ABP53010-003ml 0.03ml
EUR 158.00
Description: A polyclonal antibody for detection of SLAM from Human. This SLAM antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the region of human SLAM

SLAM Polyclonal Antibody

ABP53010-01ml 0.1ml
EUR 289.00
Description: A polyclonal antibody for detection of SLAM from Human. This SLAM antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the region of human SLAM

SLAM Polyclonal Antibody

ABP53010-02ml 0.2ml
EUR 414.00
Description: A polyclonal antibody for detection of SLAM from Human. This SLAM antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the region of human SLAM

SLAM Polyclonal Antibody

ES4009-100ul 100ul
EUR 279.00
Description: A Rabbit Polyclonal antibody against SLAM from . This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

SLAM Polyclonal Antibody

ES4009-50ul 50ul
EUR 207.00
Description: A Rabbit Polyclonal antibody against SLAM from . This antibody is tested and validated for WB, ELISA, IHC, WB, ELISA

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280.00

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280.00

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280.00

SLAM/CD150 ELISA KIT|Human

EF000089 96 Tests
EUR 689.00

Polyclonal Goat Anti-SH2D1A/SLAM associated protein Antibody

APG00307G 0.1mg
EUR 484.00
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human Goat Anti-SH2D1A/SLAM associated protein . This antibody is tested and proven to work in the following applications:

SLAM / CD150 (pY281) Antibody

abx218601-100ug 100 ug
EUR 439.00

Polyclonal SLAM/CD150 Antibody

APR11172G 0.1mg
EUR 484.00
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human SLAM/CD150 . This antibody is tested and proven to work in the following applications:

SLAM Polyclonal Conjugated Antibody

C41685 100ul
EUR 397.00

ELISA kit for Human SLAM/CD150

EK5604 96 tests
EUR 553.00
Description: Enzyme-linked immunosorbent assay kit for quantification of Human SLAM/CD150 in samples from serum, plasma, tissue homogenates and other biological fluids.

Human SLAM/CD150 PicoKine ELISA Kit

EK1321 96 wells
EUR 425.00
Description: For quantitative detection of human SLAM in cell culture supernates, cell lysates, serum and plasma (heparin, EDTA).

Recombinant human SLAM family member 7 

P1606 100ug Ask for price
Description: Recombinant protein for human SLAM family member 7 

Recombinant human SLAM family member 7

P1667 100ug Ask for price
Description: Recombinant protein for human SLAM family member 7

SLAM/CD150 ELISA Kit (Human) (OKBB00602)

OKBB00602 96 Wells
EUR 505.00
Description: Description of target: Signaling lymphocytic activation molecule is a protein that in humans is encoded by the SLAMF1 gene. It belongs to the immunoglobulin gene superfamily. This gene is mapped to 1q23.3. It has found that SLAM is constitutively expressed on peripheral blood memory T cells, T-cell clones, immature thymocytes and a proportion of B cells, and is rapidly induced on naive T cells after activation. In MV-resistant cell lines, infection with clinical MV and expression of SLAM, but not CD46, caused cytopathic effects (CPE). The expression of SLAM on activated B and T lymphocytes correlates with the pathology of MV infection in humans and monkeys, in which lymphoid organs are the chief sites of MV replication and the binding of MV to SLAM may impair the signaling functions of SLAM in lymphocyte activation and inhibit Th0/Th1 cytokine production, thereby promoting Th2 cytokine production. It has reported that antibody-mediated ligation of SLAM on thymocytes triggered a protein tyrosine phosphorylation signal in T cells in a SAP-dependent manner. This signal also involved SHIP, the adaptor molecules DOK2, DOK1, and SHC and RASGAP.;Species reactivity: Human;Application: ELISA;Assay info: Assay Methodology: Quantitative Sandwich Immunoassay;Sensitivity: <= 10 pg/mL

Phospho-SLAM/CD150 (Tyr281) Antibody

AF8512 200ul
EUR 376.00
Description: SLAM/CD150 (Phospho-Tyr281) Antibody detects endogenous levels of SLAM/CD150 only when phosphorylated at Tyr281.

SLAM/CD150 (Phospho- Tyr281) Antibody

ABF8512 100 ug
EUR 438.00

Human SLAM family member 7(SLAMF7) ELISA kit

CSB-EL021369HU-24T 1 plate of 24 wells
EUR 165.00
Description: Quantitativesandwich ELISA kit for measuring Human SLAM family member 7 (SLAMF7) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human SLAM family member 7(SLAMF7) ELISA kit

1-CSB-EL021369HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 0
  • 1
  • 2
Description: Quantitativesandwich ELISA kit for measuring Human SLAM family member 7(SLAMF7) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human SLAM family member 5, CD84 ELISA KIT

ELI-19877h 96 Tests
EUR 824.00

Human SLAM family member 9, SLAMF9 ELISA KIT

ELI-29597h 96 Tests
EUR 824.00

Human SLAM family member 8, SLAMF8 ELISA KIT

ELI-30362h 96 Tests
EUR 824.00

Human SLAM family member 7, SLAMF7 ELISA KIT

ELI-52335h 96 Tests
EUR 824.00

Human SLAM family member 5(CD84) ELISA kit

CSB-EL004964HU-24T 1 plate of 24 wells
EUR 165.00
Description: Quantitativesandwich ELISA kit for measuring Human SLAM family member 5 (CD84) in samples from serum, plasma, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human SLAM family member 5(CD84) ELISA kit

1-CSB-EL004964HU
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 0
  • 1
  • 2
Description: Quantitativesandwich ELISA kit for measuring Human SLAM family member 5(CD84) in samples from serum, plasma, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Human SLAM Family Member 5 (CD84) ELISA Kit

abx386402-96tests 96 tests
EUR 911.00

Human SLAM family member 6, SLAMF6 ELISA KIT

ELI-40997h 96 Tests
EUR 824.00

Mouse SLAM family member 7 (Slamf7)

1-CSB-EP021369MO1
  • EUR 380.00
  • EUR 214.00
  • EUR 1309.00
  • EUR 560.00
  • EUR 873.00
  • EUR 262.00
  • 0
  • 1
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  • 3
  • 4
  • 5
Description: Recombinant Mouse SLAM family member 7(Slamf7),partial expressed in E.coli

SLAM Family Member 8 (SLAMF8) Antibody

abx027070-400ul 400 ul
EUR 523.00

SLAM Family Member 8 (SLAMF8) Antibody

abx027070-80l 80 µl
EUR 286.00

SLAM Family Member 6 (SLAMF6) Antibody

20-abx126554
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 0
  • 1
  • 2
  • 3

SLAM Family Member 7 (CD319) Antibody

20-abx142227
  • EUR 370.00
  • EUR 606.00
  • EUR 314.00
  • 0
  • 1
  • 2

SLAM Family Member 6 (SLAMF6) Antibody

abx028571-400ul 400 ul
EUR 523.00

SLAM Family Member 6 (SLAMF6) Antibody

abx028571-80l 80 µl
EUR 286.00

SLAM Family Member 6 (SLAMF6) Antibody

20-abx338635
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 0
  • 1
  • 2
  • 3
  • 4

SLAM Family Member 8 (SLAMF8) Antibody

20-abx339864
  • EUR 411.00
  • EUR 300.00
  • 0
  • 1

SLAM Family Member 8 (SLAMF8) Antibody

20-abx339865
  • EUR 411.00
  • EUR 300.00
  • 0
  • 1

SLAM Family Member 8 (SLAMF8) Antibody

abx432189-200ul 200 ul
EUR 384.00

SLAM Family Member 8 (SLAMF8) Antibody

abx433278-200ul 200 ul
EUR 384.00

SLAM Family Member 8 (SLAMF8) Antibody

20-abx301283
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 0
  • 1
  • 2
  • 3
  • 4

Phospho-SLAM/CD150 (Tyr281) Blocking Peptide

AF8512-BP 1mg
EUR 195.00

Recombinant Mouse SLAM/CD150 (C-6His)

CS22-10ug 10ug
EUR 146.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse SLAM/CD150 (C-6His)

CS22-1mg 1mg
EUR 2283.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse SLAM/CD150 (C-6His)

CS22-500ug 500ug
EUR 1613.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant Mouse SLAM/CD150 (C-6His)

CS22-50ug 50ug
EUR 303.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS,pH7.4.

Recombinant mouse SLAM family member 7

P2612 100ug Ask for price
Description: Recombinant protein for mouse SLAM family member 7

Recombinant Human SLAM Family Member 2/CD48 (C-mFc)

CW29-10ug 10ug
EUR 146.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human SLAM Family Member 2/CD48 (C-mFc)

CW29-1mg 1mg
EUR 2283.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human SLAM Family Member 2/CD48 (C-mFc)

CW29-500ug 500ug
EUR 1613.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Recombinant Human SLAM Family Member 2/CD48 (C-mFc)

CW29-50ug 50ug
EUR 303.00
Description: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.

Human SLAM/CD150(Signaling Lymphocytic Activation Molecule) ELISA Kit

EH0112 96T
EUR 524.10
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens;Sensitivity: 0.094 ng/ml
  • Whereas the sequence of the HCMV genome has been identified for over a decade, the total set of viral and mobile proteins that compose the HCMV virion are unknown. To strategy this downside we’ve utilized gel-free two-dimensional capillary liquid chromatography-tandem mass spectrometry (MS/MS) and Fourier remodel ion cyclotron resonance MS to establish and decide the relative abundances of viral and mobile proteins in purified HCMV AD169 virions and dense our bodies.

 

  • Evaluation of the proteins from purified HCMV virion preparations has indicated that the particle comprises considerably extra viral proteins than beforehand identified. On this research, we recognized 71 HCMV-encoded proteins that included 12 proteins encoded by identified viral open studying frames (ORFs) beforehand not related to virions and 12 proteins from novel viral ORFs. Evaluation of the relative abundance of HCMV proteins indicated that the predominant virion protein was the pp65 tegument protein and that gM somewhat than gB was essentially the most considerable glycoprotein.

 

  • We have now additionally recognized over 70 host mobile proteins in HCMV virions, which embrace mobile structural proteins, enzymes, and chaperones. As well as, evaluation of HCMV dense our bodies indicated that these viral particles are composed of 29 viral proteins with a diminished amount of mobile proteins compared to HCMV virions. This research gives the primary complete quantitative evaluation of the viral and mobile proteins that compose infectious particles of a big advanced virus.