Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles

HIV pseudotypes bearing native hepatitis C virus (HCV) glycoproteins (pressure H and Con1) are infectious for the human hepatoma cell traces Huh-7 and PLC/PR5. Infectivity will depend on coexpression of each E1 and E2 glycoproteins, is pH-dependent, and could be neutralized by mAbs mapping to amino acids 412-447 inside E2.

Cell-surface expression of 1 or all the candidate receptor molecules (CD81, low-density lipoprotein receptor, scavenger receptor class B sort 1, and dendritic cell-specific intercellular adhesion molecule three grabbing nonintegrin) didn’t confer permissivity to HIV-HCV pseudotype an infection. Nonetheless, HIV-HCV pseudotype infectivity was inhibited by a recombinant soluble type of CD81 and a mAb particular for CD81, suggesting that CD81 could also be a element of a receptor advanced.

Prophylactic quadrivalent human papillomavirus (varieties 6, 11, 16, and 18) L1 virus-like particle vaccine in younger girls: a randomised double-blind placebo-controlled multicentre part II efficacy trial.

• The unprocessed Gag precursor from HIV-1, when expressed in recombinant baculovirus-infected insect cells, is focused to the plasma membrane and assembles in 100-120 nm particles budding from the cell floor.

• This course of mimics HIV immature particle formation and depends on myristoylation of the N-terminal glycine, as deletion of the latter leads to particle accumulation within the cytoplasm and, curiously, within the nucleus, pointing to a possible function of this non-fatty-acid-acylated species within the viral life cycle. Inclusion of the pol gene within the assemble leads to environment friendly processing of Pr55gag and a pronounced lower in particle formation.

• Deletion of the C terminus (p16) of the Gag precursor, together with the finger domains, abolishes particle meeting, however membrane focusing on and evagination nonetheless happen. Heterologous expression in insect cells might show very helpful for the examine of the molecular occasions resulting in retroviral particle morphogenesis.
• We beforehand described a kinesin-dependent motion of particles within the flagella of Chlamydomonas reinhardtii referred to as intraflagellar transport (IFT) (Kozminski, Ok.G., Ok.A. Johnson, P. Forscher, and J.L. Rosenbaum.

RELM beta protein
30R-2671	Fitzgerald	25 ug	EUR 325
Description: Purified recombinant Human RELM beta protein

RELM beta protein
30R-2672	Fitzgerald	25 ug	EUR 383
Description: Purified recombinant Human RELM beta protein

RELM beta protein
30R-AR015	Fitzgerald	25 ug	EUR 273
Description: Purified recombinant Human RELM beta protein

RELM beta protein
30R-AR018	Fitzgerald	25 ug	EUR 273
Description: Purified recombinant Human RELM beta protein

RELM beta antibody
70R-12403	Fitzgerald	100 ug	EUR 403
Description: Rabbit polyclonal RELM beta antibody

RELM-beta Antibody
5654-100	Biovision		EUR 316

RELM-beta Antibody
5654-30T	Biovision		EUR 146

RELM beta antibody
70R-RR006	Fitzgerald	50 ug	EUR 273
Description: Affinity purified Rabbit polyclonal RELM beta antibody

RELM beta antibody
70R-RR010	Fitzgerald	50 ug	EUR 273
Description: Affinity purified Rabbit polyclonal RELM beta antibody

RELM beta antibody
70R-RR027	Fitzgerald	100 ug	EUR 300
Description: Affinity purified Rabbit polyclonal RELM beta antibody

RELM beta Protein
20-abx261782	Abbexa	EUR 4114.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

RELM beta Protein
20-abx261853	Abbexa	EUR 4448.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

RELM beta Protein
20-abx262084	Abbexa	EUR 4963.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

rHu RELM-beta
AK9085-0005	Akron Biotech	5µg	Ask for price

rHu RELM-beta
AK9085-0025	Akron Biotech	25µg	Ask for price

rHu RELM-beta
AK9085-0100	Akron Biotech	100µg	Ask for price

rHu RELM-beta
AK9085-1000	Akron Biotech	1mg	Ask for price

RELM-Beta Mouse Recombinant Protein
PROTQ99P86	BosterBio	Regular: 25ug	EUR 317
Description: Mouse RELM-b Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 83 amino acids and having a molecular mass of 8.9kDa. ;The Mouse RETNLB is purified by proprietary chromatographic techniques.

Recombinant Human RELM-beta
7-01510	CHI Scientific	5µg	Ask for price

Recombinant Human RELM-beta
7-01511	CHI Scientific	25µg	Ask for price

Recombinant Human RELM-beta
7-01512	CHI Scientific	1mg	Ask for price

RELM-beta, human recombinant
4654-100	Biovision		EUR 697

RELM-beta, human recombinant
4654-1000	Biovision		EUR 3258

RELM-beta, human recombinant
4654-25	Biovision		EUR 245

RELM-beta, murine recombinant
4655-100	Biovision		EUR 936

RELM-beta, murine recombinant
4655-1000	Biovision		EUR 4432

RELM-beta, murine recombinant
4655-25	Biovision		EUR 327

Polyclonal RELM-beta Antibody
APR00311G	Leading Biology	0.1mg	EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human RELM-beta . This antibody is tested and proven to work in the following applications:

Rabbit Anti-Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) antiserum #1
RELMB21-S	Alpha Diagnostics	100 ul	EUR 457

Recombinant Murine RELM Beta Protein
PROTQ99P86-1	BosterBio	25ug	EUR 317
Description: RELMβ (Resistin-like molecule β/FIZZ2) is an 18 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ, and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver (Rajala, M. et al. J. Clin. Invest. Vol. 111, 225-230 (2003)). Interestingly the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokine Resistin and RELMβ. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Murine RELMβ is an 18.0 kDa, consisting of two 83 amino acid residue chains.

RELM-Beta Human Recombinant Protein
PROTQ9BQ08-1	BosterBio	Regular: 25ug	EUR 317
Description: RELM-b Human Recombinant produced in E.Coli is a disulfide-linked homodimer, non-glycosylated, polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 19kDa. ;RELM-b is purified by proprietary chromatographic techniques.

Recombinant Human RELM Beta Protein
PROTQ9BQ08-2	BosterBio	25ug	EUR 317
Description: Human RELMβ is a 19.0 kDa disulfide-linked homodimeric protein expressed in the epithelium of the colon and small bowel. The biological functions of RELMβ and its molecular targets, are not fully known but, it has been suggested that it plays a regulatory role during inflammation and may also act to establish links among adipose tissue, the intestine and the liver. Interestingly the molecular structure of RELMβ is highly homologous to that of the adipose-derived cytokine Resistin and RELMα. These proteins share a highly conserved C-terminal domain, characterized by 10 cysteine residues with a unique spacing motif of C-X11-C-X8-C-X-C-X3-C-X10-C-X-C-X-C-X9-C-C. Recombinant Human RELMβ is a disulfide-linked homodimer with a total molecular weight of 19.0 kDa, consisting of two 89 amino acid residue chains.

Polyclonal FIZZ1 / RELM-Beta Antibody (Internal)
APG01062G	Leading Biology	0.05mg	EUR 484
Description: A polyclonal antibody raised in Goat that recognizes and binds to Human FIZZ1 / RELM-Beta (Internal). This antibody is tested and proven to work in the following applications:

Rabbit Anti-Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) IgG#1, aff. pure
RELMB21-A	Alpha Diagnostics	100 ug	EUR 482

Rabbit Polyclonal antibody Anti-CRBN
Anti-CRBN	ImmunoStep	50 µg	EUR 349

Rabbit Anti-Human Resistin-Like protein beta (RELM-beta/FIZZ2) antiserum #2
RELMB22-S	Alpha Diagnostics	100 ul	EUR 457

RELM-Beta Human Recombinant Protein, His Tag
PROTQ9BQ08	BosterBio	Regular: 25ug	EUR 317
Description: RELM-beta Human Recombinant is a His-Tagged Fusion Protein which is 11 kDa protein containing 90 amino acid residues of the RELM-beta human and 12 additional amino acid residues - HisTag (underlined).

Recombinant Mouse RELM-alpha
7-01504	CHI Scientific	5µg	Ask for price

Recombinant Mouse RELM-alpha
7-01505	CHI Scientific	25µg	Ask for price

Recombinant Mouse RELM-alpha
7-01506	CHI Scientific	1mg	Ask for price

Recombinant Mouse RELM-Gamma
7-01516	CHI Scientific	5µg	Ask for price

Recombinant Mouse RELM-Gamma
7-01517	CHI Scientific	25µg	Ask for price

Recombinant Mouse RELM-Gamma
7-01518	CHI Scientific	1mg	Ask for price

Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) control/blocking peptide #1
RELMB21-P	Alpha Diagnostics	100 ug	EUR 164

Rabbit Anti-Human Resistin-Like protein beta (RELM-beta/FIZZ2) IgG#2, aff. pure
RELMB22-A	Alpha Diagnostics	100 ug	EUR 482

ELISA kit for Human Resistin-like Molecule Beta (RELM-Beta)
KTE60803-48T	Abbkine	48T	EUR 354
Description: Quantitative sandwich ELISA for measuring Human Resistin-like Molecule Beta (RELM-Beta) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Resistin-like Molecule Beta (RELM-Beta)
KTE60803-5platesof96wells	Abbkine	5 plates of 96 wells	EUR 2252
Description: Quantitative sandwich ELISA for measuring Human Resistin-like Molecule Beta (RELM-Beta) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

ELISA kit for Human Resistin-like Molecule Beta (RELM-Beta)
KTE60803-96T	Abbkine	96T	EUR 572
Description: Quantitative sandwich ELISA for measuring Human Resistin-like Molecule Beta (RELM-Beta) in samples from cell culture supernatants, serum, whole blood, plasma and other biological fluids.

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein for WB
RELMB26-C	Alpha Diagnostics	100 ul	EUR 286

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)
RELMB26-R-25	Alpha Diagnostics	25 ug	EUR 773

Recombinant, purified, Mouse Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)
RELMB26-R-5	Alpha Diagnostics	5 ug	EUR 324

Recombinant Human RELM-beta Protein, Untagged, E.coli-100ug
QP5281-100ug	EnQuireBio	100ug	EUR 490

Recombinant Human RELM-beta Protein, Untagged, E.coli-1mg
QP5281-1mg	EnQuireBio	1mg	EUR 2856

Recombinant Human RELM-beta Protein, Untagged, E.coli-25ug
QP5281-25ug	EnQuireBio	25ug	EUR 237

Recombinant Human RELM-beta Protein, Untagged, E.coli-500ug
QP5281-500ug	EnQuireBio	500ug	EUR 1778

Recombinant Human RELM-beta Protein, Untagged, E.coli-5ug
QP5281-5ug	EnQuireBio	5ug	EUR 136

RELM-Gamma Mouse Recombinant Protein
PROTQ7TM98	BosterBio	Regular: 25ug	EUR 317
Description: RELM g Mouse Recombinant produced in E.Coli is a non glycosylated, homodimeric polypeptide chain containing 2 x 89 amino acids and having a total molecular mass of 18.9kDa. The RELM is purified by proprietary chromatographic techniques.

RELM-alpha Mouse Recombinant Protein
PROTQ9EP95	BosterBio	Regular: 25ug	EUR 317
Description: Mouse RELM-alpha Recombinant produced in E.Coli is a monomeric, non-glycosylated, polypeptide chain containing 88 amino acids and having a molecular mass of 10 kDa. The Mouse RELM-alpha is purified by proprietary chromatographic techniques.

RELM alpha protein
30R-2664	Fitzgerald	25 ug	EUR 325
Description: Purified recombinant Mouse RELM alpha protein

RELM alpha protein
30R-AR017	Fitzgerald	5 ug	EUR 127
Description: Purified recombinant murine RELM alpha protein

RELM gamma protein
30R-AR031	Fitzgerald	25 ug	EUR 273
Description: Purified recombinant Human RELM gamma protein

RELM alpha antibody
70R-12390	Fitzgerald	100 ug	EUR 403
Description: Rabbit polyclonal RELM alpha antibody

RELM-alpha Antibody
5631-100	Biovision		EUR 316

RELM-alpha Antibody
5631-30T	Biovision		EUR 146

RELM alpha antibody
70R-RR003	Fitzgerald	100 ug	EUR 300
Description: Affinity purified Rabbit polyclonal RELM alpha antibody

RELM alpha antibody
70R-RR005	Fitzgerald	50 ug	EUR 273
Description: Affinity purified Rabbit polyclonal RELM alpha antibody

RELM?, murine recombinant
7196-10	Biovision		EUR 207

RELM?, murine recombinant
7196-50	Biovision		EUR 675

RELM alpha Protein
20-abx260719	Abbexa	EUR 3418.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

RELM gamma Protein
20-abx261846	Abbexa	EUR 4448.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

RELM alpha Protein
20-abx262083	Abbexa	EUR 4963.00 EUR 328.00 EUR 230.00	1 mg 25 ug 5 ug

Polyclonal Goat anti-GST α-form
GST-ANTI-1	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST μ-form
GST-ANTI-2	Detroit R&D	50 uL	EUR 280

Polyclonal Goat anti-GST p-form
GST-ANTI-3	Detroit R&D	50 uL	EUR 280

Human Resistin-Like protein beta (RELM-beta/FIZZ2) control/blocking peptide #2
RELMB22-P	Alpha Diagnostics	100 ug	EUR 164

Recombinant Mouse RELM-alpha His Tag
7-01507	CHI Scientific	5µg	Ask for price

Recombinant Mouse RELM-alpha His Tag
7-01508	CHI Scientific	25µg	Ask for price

Recombinant Mouse RELM-alpha His Tag
7-01509	CHI Scientific	1mg	Ask for price

Recombinant, purified, Human Resistin-Like protein beta (RELM-beta/FIZZ2) Protein for WB
RELMB22-C	Alpha Diagnostics	100 ul	EUR 286

Recombinant, purified, Human Resistin-Like protein beta (RELM-beta/FIZZ2) Protein (carrier free)
RELMB25-R-25	Alpha Diagnostics	25 ug	EUR 773

• 1993. Proc. Natl. Acad. Sci. USA. 90:5519-5523). When IFT is inhibited by inactivation of a kinesin, FLA10, within the temperature-sensitive mutant, fla10, present flagella resorb and new flagella can’t be assembled.

• We report right here that: (a) the IFT-associated FLA10 protein is a subunit of a heterotrimeric kinesin; (b) IFT particles are composed of 15 polypeptides comprising two massive complexes; (c) the FLA10 kinesin-II and IFT particle polypeptides, along with being present in flagella, are extremely concentrated across the flagellar basal our bodies; and, (d) mutations affecting homologs of two of the IFT particle polypeptides in Caenorhabditis elegans lead to defects within the sensory cilia positioned on the dendritic processes of sensory neurons.

• Within the accompanying report by Pazour, G.J., C.G. Wilkerson, and G.B. Witman (1998. J. Cell Biol. 141:979-992), a Chlamydomonas mutant (fla14) is described during which solely the retrograde transport of IFT particles is disrupted, leading to assembly-defective flagella crammed with an extra of IFT particles.

• This microtubule– dependent transport course of, IFT, outlined by mutants in each the anterograde (fla10) and retrograde (fla14) transport of isolable particles, might be important for the upkeep and meeting of all eukaryotic motile flagella and nonmotile sensory cilia.